๐Ÿงฌ AI-Powered ยท Evidence-Ranked ยท 2026 Research

Your Personal Longevity Protocol
in 60 Seconds

AI synthesizes the latest research and builds a custom supplement stack, lifestyle plan, and biomarker targets โ€” personalized to your age, goals, and budget.

Generate My Protocol โ†’
โœ“ Free to generate โœ“ No email required โœ“ 2026 research base

Evidence-Tier System

Tier 1 โ€” Clinical

Human RCT evidence

Interventions with replicated randomized controlled trials in humans. High confidence, broad consensus. Foundation of any serious protocol.

Examples: Exercise, caloric restriction, Metformin, rapamycin
Tier 2 โ€” Strong Preclinical

Animal + observational data

Strong animal models plus human observational support. Effect direction established, magnitude uncertain in humans.

Examples: NMN/NR, spermidine, fisetin, alpha-ketoglutarate
Tier 3 โ€” Emerging

Early/frontier interventions

Mechanistically compelling, early human data or first trials starting. High upside potential, higher risk profile. Monitor closely.

Examples: OSK reprogramming, GDF-11, young plasma

Generate Your Protocol

Answer 12 questions โ€” your AI protocol generates in seconds.

Basics
Health
Lifestyle

For informational purposes only. Consult your physician before starting any new supplement regimen.

Built on 2026 Research

We continuously synthesize peer-reviewed research, preprints, and clinical trial data to keep your protocol current.

March 2026 Update

OSK Partial Reprogramming Enters Human Trials

ER-100 by Life Biosciences receives FDA IND approval โ€” first epigenetic reprogramming compound entering human clinical trial. Added as Tier 3 watch category.

โš ๏ธ Safety Update โ€” March 2026

D+Q Senolytic Warning Issued

Dasatinib + Quercetin (popular senolytic combo) linked to myelin loss in mouse model. Removed from default protocols; flagged for users currently taking it.

New Protocol Addition

GLP-1 for Longevity (with caveats)

GLP-1 agonists now show epigenetic age reduction + CV mortality benefits. Added with mandatory resistance training co-requirement to offset sarcopenia risk.

Sinclair Stack 2026

Updated: + Taurine 2g, + ALA

David Sinclair's 2026 stack update adds Taurine 2g/day and reintroduces ALA. Rapamycin weekly dosing confirmed. NMN maintains Tier 2 status.